VDS config best practice

Hi

I have the below config, and need to determine if it needs modification or the current config is fine as is.

We have 3 Clusters

Cluster 1

5 x Rack mount servers each with 6 VMNICs (1GBps)

2 X VMnic in standard vSwitch for management, vmotion traffic

4 X VMNIC in VDS1 for Guest traffic

Cluster 2

6 x Blade servers with 2 VMNICs (10GBps)

2 X VMNIC in VDS1 for Guest traffic and management, vmotion traffic

VDS1 has 13 port groups each with their own VLAN ID and 4 dvUplinks

My main question is around having cluster 1 and cluster 2 as part of the same VDS given the difference in physical nics 2 vs. 4.

Is there any documented issues doing it this way ?

Secondly should I create a second VDS and split the servers between these two VDS' based on their NIC count ?

Currently we do VMotions between the two clusters, will a second VDS complicate this or prevent it  ?

Thanks